GB/T 35800-2018 Translated English of Chinese Standard. (GBT 35800-2018, GB/T35800-2018, GBT35800-2018): Determination of Hexamidine, Chlorhexidine and Their Salts as Preservatives in Cosmetics - High Performance Liquid ChromatographyThis Standard specifies the method of high performance liquid chromatography of determining hexamidine, chlorhexidine and their salts as preservatives in cosmetics. This Standard is applicable to the determination of hexamidine, chlorhexidine and their salts as preservatives in aqueous, creamy, shampoo, powdered and lipstick cosmetics. The detection limit and the limit of quantitation of this Standard: the detection limit of hexamidine, chlorhexidine and their salts: 0.002%; the limit of quantitation: 0.004%. |
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0.5 g accurate 50 mL PTFE A.1 in Appendix accurate to 0.1 Acetonitrile Analytical centrifugation at 5,000 Chlorhexidine Appendix chlorhexidine standard stock chromatogram of hexamidine chromatographic peak conditions in 6.2 confirmation test constant volume detection limit determination conditions Determination of Hexamidine determination with high dilute electrospray Figure A.1 Flow rate following reference conditions GB/T hexamidine and chlorhexidine Hexamidine Diisethionate isethionate high performance liquid Information of Hexamidine ion mass chromatogram Ion source Liquid Chromatogram liquid chromatography-mass spectrometry Mass of Hexamidine Mass Spectrometry methanol 4.2 microporous membrane 5.8 mL PTFE centrifuge mL volumetric flask Mobile phase Molecular Formula performance liquid chromatography plug PTFE centrifuge tube r/min refer to Figure refer to Table Relative Molecular Mass salts as preservatives sample Weigh-take 0.5 selected ion mass specified date standard curve standard stock solution standard working solution Structural Formula Table A.1 Tetrahydrofuran Trifluoroacetic acid ultrasonic water bath vortex mixing water bath 5.3 Weigh-take 0.5 g