Antibiotics: Targets, Mechanisms and Resistance

Գրքի շապիկի երեսը
Claudio O. Gualerzi, Letizia Brandi, Attilio Fabbretti, Cynthia L. Pon
John Wiley & Sons, 05 սեպ, 2013 թ. - 576 էջ
Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed.

Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic resistance, this reference systematically covers currently known antibiotic classes, their molecular mechanisms and the targets on which they act. Novel targets such as cell signaling networks, riboswitches and bacterial chaperones are covered here, alongside the latest information on the molecular mechanisms of current blockbuster antibiotics.

With its broad overview of current and future antibacterial drug development, this unique reference is essential reading for anyone involved in the development and therapeutic application of novel antibiotics.
 

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List of Contributors
A Chemists Survey of Different Antibiotic Classes
i
References
xiii
Impact of Microbial Natural Products on Antibacterial Drug
18
References
32
Fitness Costs of Antibiotic Resistance
68
Acknowledgments
85
The Membrane as a Novel Target Site for Antibiotics to Kill
102
Targeting Ribonuclease
45
Involvement of Ribosome Biogenesis in Antibiotic Function
57
AminoacyltRNA Synthetase Inhibitors
72
References
88
Antibiotics Targeting Translation Initiation in Prokaryotes
93
Inhibitors of Bacterial Elongation Factor EFTu
112
Peptidyltransferase Inhibitors of the Bacterial Ribosome
71
Antibiotics Inhibiting the Translocation Step of Protein Elongation
89

References
90
Bacterial Membrane a Key for Controlling Drug Influx and Efflux
150
Interference with Bacterial CelltoCell Chemical Signaling
80
Recent Developments in Inhibitors of Bacterial Type
83
Inhibitors Targeting Riboswitches and Ribozymes
151
References
99
Aminoglycoside Antibiotics Structural Decoding of Inhibitors
103
Targeting HSP70 to Fight Cancer and Bad Bugs One and the Same
103
Index
105
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Claudio Gualerzi is full professor of Molecular Biology at the University of Camerino (Italy) and member of the EMBO. Following his studies at the University of Rome-La Sapienza and a postdoctoral period at the University of Pennsylvania (USA), he served as research group leader at the Max-Planck-Institute for Molecular Genetics in Berlin (Germany). He was consultant for the Lepetit Research Center in Gerenzano (Italy) and has received numerous awards and honorary lectureships, including the research prize of
the Alexander von Humboldt foundation for his work on ribosome function and the discovery of novel antibiotics

Attilio Fabbretti completed his doctoral studies at the University of Camerino (Italy) where he is now a research associate in the laboratory of Molecular Biology. He received the prize of the Italian Society for General Microbiology and Microbial Biotechnology for the best PhD thesis in 2007.

Letizia Brandi
received her doctoral degree from the University of Catania after performing her thesis work at the University of Camerino, Italy. She served a postdoctoral period at the University of Montana (Missoula, USA) and worked as a senior scientist at Biosearch Italia, spa and Vicuron Pharmaceuticals (Gerenzano, Italy), before joining the laboratory of Molecular Biology at the University of Camerino where she is now a research associate.

Cynthia Pon received her PhD from Rutgers the State University (USA). Following post-doctoral periods at the University of Pennsylvania and Hunter College of the City University of New York, she worked at the Max-Planck-Institute for Molecular Genetics in Berlin (Germany) before becoming full professor of Molecular and Microbial Genetics at the University of Camerino (Italy). Her work has focused on the mechanism of protein synthesis, global responses in bacteria and action

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