Antibiotics: Targets, Mechanisms and Resistance
Claudio O. Gualerzi, Letizia Brandi, Attilio Fabbretti, Cynthia L. Pon
John Wiley & Sons, 05 սեպ, 2013 թ. - 576 էջ
Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed.
Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic resistance, this reference systematically covers currently known antibiotic classes, their molecular mechanisms and the targets on which they act. Novel targets such as cell signaling networks, riboswitches and bacterial chaperones are covered here, alongside the latest information on the molecular mechanisms of current blockbuster antibiotics.
With its broad overview of current and future antibacterial drug development, this unique reference is essential reading for anyone involved in the development and therapeutic application of novel antibiotics.
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Antibiotics and Resistance A Fatal Attraction
Fitness Costs of Antibiotic Resistance
Inhibitors of CellWall Synthesis
Inhibitors of Bacterial Cell Partitioning
Involvement of Ribosome Biogenesis
AminoacyltRNA Synthetase Inhibitors
Antibiotics Targeting Translation Initiation
Aminoglycoside Antibiotics Structural
Peptidyltransferase Inhibitors of the Bacterial
The Membrane as a Novel Target Site
Bacterial Membrane a Key for Controlling Drug
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Recent Developments in Inhibitors of Bacterial
Antibiotics Targeting Bacterial
Inhibitors Targeting Riboswitches
Targeting HSP7O to Fight Cancer and
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Common terms and phrases
A-site Acad Agents Chemother amino acid aminoglycosides analogs antibacterial antibacterial activity antibacterial agents antibiotic resistance Antimicrob aptamer assay ATPase Bacteriol binding Biochem biofilms biogenesis Biol Bioorg biosynthesis c-di-GMP catalytic cell Chem chemical clinical complex compounds crystal structure daptomycin DNA gyrase domain drug discovery EF-Tu effect efflux pumps elongation enacyloxin encoding enzyme Escherichia coli eukaryotic factor Figure fluoroquinolones formation FtsZ function gene expression genetic gram-negative gram-negative bacteria gram-positive GyrA GyrB identified infections inhibition inhibitors of bacterial interaction isolated kasugamycin Lett ligand lysine macrolide membrane metabolism methyltransferases Microbiol molecular molecules mRNA mutations Natl natural products novel novobiocin nucleotide P-site pathogens peptide potent Proc protein synthesis Pseudomonas aeruginosa quinolone quorum sensing regulation residues ribosomal subunit riboswitch ribozyme RNA polymerase RNAP RNase rRNA screening specific Staphylococcus aureus strains Streptomyces subtilis synthetase target thiostrepton topo topoisomerase transcription translation initiation translocation tRNA virulence vitro vivo