Antibiotics: Targets, Mechanisms and Resistance

Գրքի շապիկի երեսը
Claudio O. Gualerzi, Letizia Brandi, Attilio Fabbretti, Cynthia L. Pon
John Wiley & Sons, 05 սեպ, 2013 թ. - 576 էջ
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Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed.

Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic resistance, this reference systematically covers currently known antibiotic classes, their molecular mechanisms and the targets on which they act. Novel targets such as cell signaling networks, riboswitches and bacterial chaperones are covered here, alongside the latest information on the molecular mechanisms of current blockbuster antibiotics.

With its broad overview of current and future antibacterial drug development, this unique reference is essential reading for anyone involved in the development and therapeutic application of novel antibiotics.
 

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List of Contributors
A Chemists Survey of Different Antibiotic
Antibacterial Discovery Problems
Impact of Microbial Natural Products
Antibiotics and Resistance A Fatal Attraction
Fitness Costs of Antibiotic Resistance
Inhibitors of CellWall Synthesis
Inhibitors of Bacterial Cell Partitioning
Targeting Ribonuclease
Involvement of Ribosome Biogenesis
AminoacyltRNA Synthetase Inhibitors
Antibiotics Targeting Translation Initiation
References
Aminoglycoside Antibiotics Structural
Peptidyltransferase Inhibitors of the Bacterial
References

The Membrane as a Novel Target Site
Bacterial Membrane a Key for Controlling Drug
Interference with Bacterial CelltoCell
Recent Developments in Inhibitors of Bacterial
Antibiotics Targeting Bacterial
Inhibitors Targeting Riboswitches
Acknowledgments
Targeting HSP7O to Fight Cancer and
References
Index
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Antibiotics: Targets, Mechanisms and Resistance
Claudio O. Gualerzi,Letizia Brandi,Attilio Fabbretti,Cynthia L. Pon
Դիտել հնարավոր չէ - 2013

Common terms and phrases

A-site Acad Agents Chemother amino acid aminoglycosides analogs antibacterial antibacterial activity antibacterial agents antibiotic resistance Antimicrob aptamer assay ATPase Bacteriol binding Biochem biofilms biogenesis Biol Bioorg biosynthesis c-di-GMP catalytic cell Chem chemical clinical complex compounds crystal structure daptomycin DNA gyrase domain drug discovery EF-Tu effect efflux pumps elongation enacyloxin encoding enzyme Escherichia coli eukaryotic factor Figure fluoroquinolones formation FtsZ function gene expression genetic gram-negative gram-negative bacteria gram-positive GyrA GyrB identified infections inhibition inhibitors of bacterial interaction isolated kasugamycin Lett ligand lysine macrolide membrane metabolism methyltransferases Microbiol molecular molecules mRNA mutations Natl natural products novel novobiocin nucleotide P-site pathogens peptide potent Proc protein synthesis Pseudomonas aeruginosa quinolone quorum sensing regulation residues ribosomal subunit riboswitch ribozyme RNA polymerase RNAP RNase rRNA screening specific Staphylococcus aureus strains Streptomyces subtilis synthetase target thiostrepton topo topoisomerase transcription translation initiation translocation tRNA virulence vitro vivo

Հեղինակի մասին (2013)

Claudio Gualerzi is full professor of Molecular Biology at the University of Camerino (Italy) and member of the EMBO. Following his studies at the University of Rome-La Sapienza and a postdoctoral period at the University of Pennsylvania (USA), he served as research group leader at the Max-Planck-Institute for Molecular Genetics in Berlin (Germany). He was consultant for the Lepetit Research Center in Gerenzano (Italy) and has received numerous awards and honorary lectureships, including the research prize of
the Alexander von Humboldt foundation for his work on ribosome function and the discovery of novel antibiotics

Attilio Fabbretti completed his doctoral studies at the University of Camerino (Italy) where he is now a research associate in the laboratory of Molecular Biology. He received the prize of the Italian Society for General Microbiology and Microbial Biotechnology for the best PhD thesis in 2007.

Letizia Brandi received her doctoral degree from the University of Catania after performing her thesis work at the University of Camerino, Italy. She served a postdoctoral period at the University of Montana (Missoula, USA) and worked as a senior scientist at Biosearch Italia, spa and Vicuron Pharmaceuticals (Gerenzano, Italy), before joining the laboratory of Molecular Biology at the University of Camerino where she is now a research associate.

Cynthia Pon received her PhD from Rutgers the State University (USA). Following post-doctoral periods at the University of Pennsylvania and Hunter College of the City University of New York, she worked at the Max-Planck-Institute for Molecular Genetics in Berlin (Germany) before becoming full professor of Molecular and Microbial Genetics at the University of Camerino (Italy). Her work has focused on the mechanism of protein synthesis, global responses in bacteria and action

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QR code for Antibiotics
ՎերնագիրAntibiotics: Targets, Mechanisms and Resistance
EditorsClaudio O. Gualerzi, Letizia Brandi, Attilio Fabbretti, Cynthia L. Pon
ՀրատարակիչJohn Wiley & Sons, 2013
ISBN3527659706, 9783527659708
Length576 էջ
  
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