MethotrexateBruce N. Cronstein, Joseph R. Bertino Springer Science & Business Media, 2000 - 139 էջ This book provides multidisciplinary reviews of the mechanism of action and uses of methotrexate in the treatment of cancer, psoriasis, gynecologic and inflammatory diseases. The intended audience is composed of clinicians involved in the care of patients suffering from oncologic, gynecologic, rheumatic diseases as well as scientists involved in research into the pathogenesis and treatment of these diseases. This book is unique in that it provides a single, state-of-the-art source for information regarding the mechanism and use of methotrexate in many different areas of medicine. |
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historical aspects | 1 |
Methotrexate its mechanism of action in malignant disease and mechanisms of resistance by malignant cells | 9 |
Current use of methotrexate in the treatment of malignancies in adults | 31 |
The use of methotrexate in the treatment of childhood malignancies | 49 |
The mechanisms of methotrexates action in the treatment of inflammatory disease | 65 |
Methotrexate in rheumatoid arthritis | 83 |
Use of methotrexate in the treatment of psoriasis and other dermatological disorders | 109 |
The use of methotrexate in gynecological practice | 125 |
| 137 | |
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Common terms and phrases
activity acute lymphoblastic leukemia adenosine agents Alarcón GS aminopterin antifolate Arthritis Rheum associated Bertino JR biochemical Biol Chem blasts blood Cancer Res cell lines cellular chemotherapy cisplatin Clin Oncol clinical corticosteroids cutaneous cytokines decreased dermatomyositis DHFR dihydrofolate reductase disease dose of methotrexate drug ectopic pregnancy effects of methotrexate efficacy enzyme fluorouracil folate folic acid FPGS gamma-glutamyl hydrolase gene high dose high-dose methotrexate human increased infections inflammatory inhibitor inhibits intrathecal Kamen BA leucovorin leukemia cells levels low dose methotrexate low-dose lymphocytic lymphoma malignant mercaptopurine metabolism metho methotrexate in rheumatoid methotrexate treatment mg/m² MTX polyglutamates MTX resistance neutrophils Obstet Gynecol osteosarcoma Pancytopenia patients treated patients with rheumatoid Pharmacol protein psoriasis receptors reduced folate carrier regimen reported resistance to MTX Rheum rheumatoid arthritis patients rheumatoid factor Rheumatol 20 sarcoma serum studies therapeutic therapy for rheumatoid tissue toxicity transport treated with methotrexate treatment of rheumatoid trial tubal tumors vitro