Antibiotics : targets, mechanisms and resistance
"Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed. Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic resistance, this reference systematically covers currently known antibiotic classes, their molecular mechanisms and the targets on which they act. Novel targets such as cell signaling networks, riboswitches and bacterial chaperones are covered here, alongside the latest information on the molecular mechanisms of current blockbuster antibiotics. With its broad overview of current and future antibacterial drug development, this unique reference is essential reading for anyone involved in the development and therapeutic application of novel antibiotics"--EBL
1 online resource (xxiv, 549 pages) : illustrations (some color)
9783527659685, 9781299854659, 9783527659715, 9783527333059, 9783527659708, 9783527659692, 3527659684, 1299854656, 3527659714, 3527333053, 3527659706, 3527659692
858657953
A chemist's survey of different antibiotic classes
Antibacterial discovery: problems and possibilities
Impact of microbial natural products on antibacterial drug discovery
Antibiotics and resistance: a fatal attraction
Fitness costs of antibiotic resistance
Inhibitors of cell-wall synthesis
Inhibitors of bacetrial cell partitioning
The membrane as a novel target site for antibiotics to kill persisting bacterial pathogens
Bacterial membrane, a key for controlling drug influx and efflux
Interference with bacterial cell-to-cell chemical signaling in development of new anti-infectives
Recent developments in inhibitors of bacterial type IIA topoisomerases
Antibiotics targeting bacterial RNA polymerase
Inhibitors targeting riboswitches and ribozymes
Targeting ribonuclease P
Involvement of ribosome biogenesis in antibiotic functions, acquired resistance, and future opportunities in drug discovery
Aminoacyl-tRNA synthetase inhibitors
Antibiotics targeting translation initiation in prokaryotes
Inhibitors of bacterial elongation factor EF-Tu
Aminoglycoside antibiotics: structural decoding of inhibitors targeting the ribosomal decoding A site
Reptidyltransferase inhibitors of the bacterial ribosome
Antibiotics inhibiting the translocation step of protein elongation on the ribosome
Antibiotics at the ribosomal exit tunnel
selected structual aspects
Targeting HSP70 to fight cancer and bad bugs: one and the same battle?